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Toshio Hattori Selected Research

brefelamide

4/2020Downregulation of PD-L1 via amide analogues of brefelamide: Alternatives to antibody-based cancer immunotherapy.
1/2017Induction of Osteopontin by Dengue Virus-3 Infection in THP-1 Cells: Inhibition of the Synthesis by Brefelamide and Its Derivative.
10/2016Identification of brefelamide as a novel inhibitor of osteopontin that suppresses invasion of A549 lung cancer cells.

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Toshio Hattori Research Topics

Disease

21Infections
01/2022 - 03/2002
15Tuberculosis (Tuberculoses)
10/2020 - 03/2008
8Neoplasms (Cancer)
01/2022 - 06/2010
8Inflammation (Inflammations)
08/2021 - 01/2005
6Acquired Immunodeficiency Syndrome (AIDS)
08/2021 - 01/2008
5Latent Tuberculosis
01/2020 - 01/2010
4COVID-19
02/2023 - 01/2021
4Leptospirosis
08/2021 - 04/2016
4Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
08/2021 - 11/2011
4Coinfection
10/2020 - 12/2007
4Disease Progression
01/2020 - 04/2004
4T-Cell Leukemia (Leukemia, T Cell)
05/2011 - 12/2007
3Communicable Diseases (Infectious Diseases)
08/2021 - 01/2017
3HIV Infections (HIV Infection)
01/2020 - 04/2004
3Granuloma
10/2019 - 10/2015
3Pulmonary Tuberculosis
12/2016 - 03/2008
3Neoplasm Metastasis (Metastasis)
10/2016 - 06/2010
3Chronic Obstructive Pulmonary Disease (COPD)
01/2007 - 01/2004
2Pneumonia (Pneumonitis)
02/2023 - 05/2021
2Cytokine Release Syndrome
01/2021 - 02/2015
2Dengue (Dengue Fever)
03/2019 - 01/2017
2Necrosis
06/2017 - 07/2005
2Lung Neoplasms (Lung Cancer)
10/2016 - 01/2007
2Hepatocellular Carcinoma (Hepatoma)
04/2016 - 09/2008
2Edema (Dropsy)
01/2016 - 02/2015
2Carcinogenesis
10/2015 - 09/2008
2Eosinophilia
08/2010 - 03/2003
2Asthma (Bronchial Asthma)
01/2004 - 03/2003
1Psoriasis (Pustulosis Palmaris et Plantaris)
12/2023
1Respiratory Insufficiency (Respiratory Failure)
01/2021
1Esophageal Neoplasms (Esophageal Cancer)
02/2020
1Viremia
01/2020
1Pleural Effusion (Pleural Effusions)
06/2017

Drug/Important Bio-Agent (IBA)

24OsteopontinIBA
08/2021 - 08/2009
13Proteins (Proteins, Gene)FDA Link
10/2020 - 01/2004
11CytokinesIBA
10/2020 - 01/2005
10Biomarkers (Surrogate Marker)IBA
02/2023 - 04/2006
6Peptide Hydrolases (Proteases)FDA Link
02/2023 - 04/2004
6AntibodiesIBA
01/2017 - 03/2008
5EnzymesIBA
12/2023 - 01/2007
5Antiviral Agents (Antivirals)IBA
02/2023 - 02/2006
5Immunoglobulin G (IgG)IBA
01/2017 - 01/2008
5AntigensIBA
01/2017 - 01/2008
5GlycolipidsIBA
01/2015 - 01/2008
5tax Gene Products (tax Gene Product)IBA
11/2011 - 12/2007
4Therapeutic UsesIBA
02/2023 - 12/2013
4ThrombinFDA Link
08/2021 - 04/2004
4InterferonsIBA
06/2017 - 09/2008
3ImmunosorbentsIBA
12/2023 - 04/2016
3ChemokinesIBA
10/2020 - 01/2007
3brefelamideIBA
04/2020 - 10/2016
3Messenger RNA (mRNA)IBA
04/2020 - 01/2007
3Immunoglobulin A (IgA)IBA
01/2015 - 03/2008
2Interleukin-2 Receptors (IL 2 Receptor)IBA
02/2023 - 01/2012
2tocilizumab (atlizumab)FDA Link
02/2023 - 05/2021
2Oxygen (Dioxygen)IBA
02/2023 - 03/2003
2Ferritins (Ferritin)IBA
02/2023 - 08/2014
2Peptides (Polypeptides)IBA
02/2023 - 09/2002
2fibrin fragment D (D-dimer)IBA
02/2023 - 08/2014
2Galectins (Galectin)IBA
01/2022 - 07/2017
2Indicators and Reagents (Reagents)IBA
01/2021 - 04/2016
2Interleukin-17 (Interleukin 17)IBA
10/2020 - 01/2015
2Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
10/2020 - 01/2007
2InterleukinsIBA
10/2020 - 01/2017
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2017 - 01/2005
2lipoarabinomannan (LAM)IBA
01/2017 - 01/2015
2Interferon-gamma (Interferon, gamma)IBA
01/2010 - 01/2005
2Butanols (Butyl Alcohols)IBA
04/2009 - 02/2009
2CC ChemokinesIBA
09/2008 - 01/2007
2Interleukin-1beta (Interleukin 1 beta)IBA
01/2007 - 01/2005
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
04/2006 - 07/2005
2EpitopesIBA
04/2005 - 04/2004
1Alanine Transaminase (SGPT)IBA
12/2023
1Immune Checkpoint ProteinsIBA
12/2023
1CarbohydratesIBA
02/2023
1C-Reactive ProteinIBA
02/2023
1Metalloproteases (Metalloproteinases)IBA
02/2023
1LectinsIBA
01/2021
1Blocking AntibodiesIBA
01/2021
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
10/2020
1Transforming Growth Factors (Transforming Growth Factor)IBA
10/2020
1Interleukin-6 (Interleukin 6)IBA
10/2020
1N 30IBA
06/2020
1CreatinineIBA
06/2020
1Cystatin CIBA
06/2020
1Hexosaminidases (Hexosaminidase)IBA
06/2020
1ClusterinIBA
06/2020
1Interleukin-2 (IL2)IBA
04/2020
1Immune Checkpoint InhibitorsIBA
04/2020
1AmidesIBA
04/2020
1RNA (Ribonucleic Acid)IBA
03/2019
1phorbolIBA
01/2018
1Carrier Proteins (Binding Protein)IBA
07/2017
1LactoseFDA LinkGeneric
06/2017

Therapy/Procedure

11Therapeutics
08/2021 - 04/2004
3Immunotherapy
01/2021 - 11/2015
2Drug Therapy (Chemotherapy)
02/2020 - 01/2017
2Highly Active Antiretroviral Therapy (HAART)
08/2007 - 03/2002
1Complementary Therapies (Alternative Medicine)
02/2020
1Art Therapy
01/2020